SGO1 Antibody

SGO1

hSgo 1 antibody; hSgo1 antibody; NY BR 85 antibody; Serologically defined breast cancer antigen NY BR 85 antibody; Serologically defined breast cancer antigen NY-BR-85 antibody; SGO 1 antibody; SGO antibody; SGO L1 antibody; SGO1 antibody; SGOL 1 antibody; SGOL1 antibody; SGOL1_HUMAN antibody; Shugoshin 1AB protein antibody; Shugoshin 1CD protein antibody; Shugoshin 1EFprotein antibody; Shugoshin 1GH protein antibody; Shugoshin 1KL protein antibody; Shugoshin like 1 (S. pombe) antibody; Shugoshin like 1 antibody; Shugoshin-like 1 antibody

Recombinant Human Shugoshin 1 protein (260-439AA)

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.

>95%, Protein G purified

Epigenetics and Nuclear Signaling

Recombinant Human Shugoshin 1 protein (260-439AA)