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Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase(Cyp17a1)

Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase(Cyp17a1)

Manufacturer	Cusabio
Category	Oncology Food Safety Hormones Peptides & Proteins Recombinant Proteins By Organ Testicular & Prostate Cancer
Type	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Amount	200ug
Host	E.coli
Item no.	CSB-EP006392RA-200
eClass 6.1	34160400
eClass 9.0	42020190
Available
Research Topic	Metabolism
Uniprot ID	P11715
Gene Names	Cyp17a1
Organism	Rattus norvegicus (Rat)
AA Sequence	MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLP LVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGT TTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLL SDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQK LEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVT NIICAICFNISYEKNDPKLTAIKTFTEGIVDATGD RNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGI FEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEG RDPDVFSDRHILATVGDIFGAGIETTTTVLKWILA FLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLL MLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTV PKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFT ALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKV KITVRQAWMDAQAEVST
Expression Region	1-507aa
Sequence Info	Full Length
Source	E.coli
Tag Info	N-terminal 6xHis-SUMO-tagged
MW	73.3 kDa
Alternative Name(s)	17-alpha-hydroxyprogesterone aldolase CYPXVII Cytochrome P450 17A1 Cytochrome P450-C17 Short name: Cytochrome P450c17
Relevance	Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17, 20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Reference	"Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17, 20-lyase reactions."Fevold H.R., Lorence M.C., McCarthy J.L., Trant J.M., Kagimoto M., Waterman M.R., Mason J.I.Mol. Endocrinol. 3:968-975(1989)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	Tris-based buffer, 50% glycerol
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17, 20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Subcellular Location	Membrane
Protein Families	Cytochrome P450 family
Tag Information	N-terminal 6xHis-SUMO-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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