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Recombinant Human Major vault protein(MVP)

Recombinant Human Major vault protein(MVP)

Manufacturer	Cusabio
Category	Oncology Neuroscience Targets for Rodent Neurosciences Peptides & Proteins Recombinant Proteins By Organ Lung Cancer
Type	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Amount	100ug
Host	E.coli
Item no.	CSB-EP015248HU-100
eClass 6.1	34160400
eClass 9.0	42020190
Available
Research Areas	Transport
Uniprot ID	Q14764
Gene Names	MVP
Organism	Homo sapiens (Human)
AA Sequence	ATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYI RQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQG LVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLE KDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGD EWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRL RARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEE VLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTG EEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNY CVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQL EQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSH QAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENE GIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPP GVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTR VVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGP EEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDV ITIETADHARLQLQLAYNWHFEVNDRKDPQETAKL FSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSA RIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQN GLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITT NSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEK ARKELLELEALSMAVESTGTAKAEAESRAEAARIE GEGSVLQAKLKAQALAIETEAELQRVQKVRELELV YARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPST IRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINL FNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQS AQAPQAPGDNHVVPVLR
Expression Region	2-893aa
Sequence Info	Full Length of Mature Protein
Source	E.coli
Tag Info	N-terminal 6xHis-SUMO-tagged
MW	115.2 kDa
Alternative Name(s)	Lung resistance-related protein
Relevance	Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-Cytoplasmic domain transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Reference	An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)
Purity	Greater than 90% as determined by SDS-PAGE.
Form	Liquid or Lyophilized powder
Buffer	If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Subcellular Location	Cytoplasm, Nucleus, nuclear pore complex, Cytoplasm, perinuclear region
Tissue Specificity	Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Tag Information	N-terminal 6xHis-SUMO-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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