Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Format |
Liquid or Lyophilized powder |
Amount |
200ug |
Host |
E.coli |
Item no. |
CSB-EP016025RA1-200 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research Topic |
Others |
Uniprot ID |
P41740 |
Gene Names |
Npr3 |
Organism |
Rattus norvegicus (Rat) |
AA Sequence |
EALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYAL RSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFS LVDRVAAARGAKPDLILGPVCEYAAAPVARLASHW DLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMG EMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGV HEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSE RVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIE LFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLL RTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEG FHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNR TFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQE VIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIV EHTNSSPCKSCGLEESA |
Expression Region |
41-477aa |
Sequence Info |
Extracellular Domain |
Source |
E.coli |
Tag Info |
N-terminal 6xHis-SUMO-tagged |
MW |
64.9 kDa |
Alternative Name(s) |
Atrial natriuretic peptide clearance receptorAtrial natriuretic peptide receptor type C ; ANP-C ; ANPR-C ; NPR-C |
Relevance |
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity . |
Reference |
A single residue determines the distinct pharmacology of rat and human natriuretic peptide receptor-C.Engel A.M., Schoenfeld J.R., Lowe D.G.J. Biol. Chem. 269:17005-17008(1994) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage Buffer |
Tris-based buffer, 50% glycerol |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. |
Subcellular Location |
Membrane, Single-pass type I membrane protein |
Protein Families |
ANF receptor family |
Tag Information |
N-terminal 6xHis-SUMO-tagged |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.