|
Manufacturer |
Cusabio
|
|
Category |
|
|
Type |
Proteins |
|
Specific against |
other |
|
Amount |
200ug |
|
Host |
E.coli |
|
Item no. |
CSB-EP016058HU-200 |
|
eClass 6.1 |
34160400 |
|
eClass 9.0 |
42020190 |
|
Available |
 |
| Alternative Name(s) |
V-erbA-related protein 2
Short name:
EAR-2 |
| AA Sequence |
MAMVTGGWGGPGGDTNGVDKAGGYPRAAEDDSASP PGAASDAEPGDEERPGLQVDCVVCGDKSSGKHYGV FTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHR NQCQYCRLKKCFRVGMRKEAVQRGRIPHSLPGAVA ASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLR AEPYPAAAGRFGAGGGAAGAVLGIDNVCELAARLL FSTVEWARHAPFFPELPVADQVALLRLSWSELFVL NAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMD QVRAFQEQVDKLGRLQVDSAEYGCLKAIALFTPDA CGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRF GRLLLRLPALRAVPASLISQLFFMRLVGKTPIETL IRDMLLSGSTFNWPYGSGQ |
| Research Topic |
Epigenetics and Nuclear Signaling |
| Uniprot ID |
P10588 |
| Gene Names |
NR2F6 |
| Tag Info |
N-terminal 6xHis-SUMO-tagged |
| Expression Region |
1-404aa |
| MW of Fusion Proten |
59 |
| Sequence Info |
Full Length |
| Relevance |
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). |
| Reference |
"Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other."Miyajima N., Kadowaki Y., Fukushige S., Shimizu S., Semba K., Yamanashi Y., Matsubara K., Toyoshima K., Yamamoto T.Nucleic Acids Res. 16:11057-11074(1988) |
| Purity |
Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer |
Tris-based buffer, 50% glycerol |
| Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
| Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
| Species |
Homo sapiens (Human) |
