EN40

Manufacturer	ChemScene
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Amount	5mg
Item no.	CS-0087195-5mg
eClass 6.1	32169090
eClass 9.0	32169090
Available
CAS	2094547-67-6
Purity	>98%
MWt	217.26
Formula	C13H15NO2
Solubility	DMSO : 5 mg/mL (23.01 mM; Need ultrasonic); Ethanol : 2 mg/mL (9.21 mM; Need ultrasonic)
Clinical Information	No Development Reported
Pathway	Metabolic Enzyme/Protease
Target	Aldehyde Dehydrogenase (ALDH)
Biological Activity	EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC₅₀ value of 2 uM^[1] IC50 & Target: IC50: 2 uM (ALDH3A1)^[1] In Vitro: EN40 (10-1000 uM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival^[1]. In Vivo: EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice^[1].
Research Area	Cancer

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Delivery expected until 6/6/2024