4BioDX

IVF

SPQI S.A.S. (Services and Products of Quality and Innovative), based in Lille (North of France), is a spin-off company of the research institute "Institut National de la Santé et de la Recherche Médicale" and is located in the hospital of Lille. Its focus is on monoclonal, polyclonal antibodies and ELISA kits.

SPQI-4BioDx represents a specialized line of the company under which the 4MID® kits are sold. The kits are used for functional and quality testing of (animal) semen and male fertility.

The 4MID® Kits can be used with raw, cooled and frozen semen in extenders and thus offer the possibility to (re)process and analyze even stored samples. The small sample volume of only 25 to 50 µl per analysis guarantees good laboratory practice. The test kits are available for many animals as well as for human applications. Examples of animals are: Rodents, camels (camelids), wild boars, stallions, bulls, billy goats, rams, dogs and cats (all felines).

proAKAP4 ELISA - Rodent and human proAKAP4 (4BDX-18K12RUO)

Anti-phospho-tau antibodies as biomarkers in neurodegenerative diseases

Tau proteins regulate microtubule polymerization and stability. In Alzheimer's disease, the epitope serine-422 is phosphorylated (pS422) and tau proteins aggregate into filaments. The abnormal phosphorylation site of S422 is found in neurofibrillary degeneration, and pS422 correlates with the severity of Alzheimer's disease. The mouse monoclonal antibody (clone 2H9, Cat.# Cat.# 4BDX-1502) specifically binds pS422. The antibody is suitable for immunoblotting of pS422 in brain homogenates or for immunotherapy of experimental models of tauopathy and currently represents the only mouse mAb for neurofibrillary degeneration.

The pathological epitope pS422 of the tau protein has particular importance as it is implicated in many neurodegenerative diseases. To list a few examples:

In all of the pathological conditions listed here, there is a mutation of the MAPT gene, which encodes the tau protein. This demonstrates the importance of the antibody (Cat.# 4BDX-1501) for neurodegenerative disease research.

Phospho-Serine-199 (Cat.# 4BDX-1502) was found to be an early biomarker for neurofibrillary degeneration in Alzheimer's patients and other tauopathies, interestingly also in young individuals.

Antiphospho-[ß-amyloid precursor protein] antibodies as biomarkers for neurodegenerative diseases

The ß-amyloid precursor protein (APP) is a well-conserved and ubiquitous transmembrane glycoprotein with multiple isoforms and is strongly implicated in the pathogenesis and development of Alzheimer's disease. APP, as well as its associated proteins amyloid-like protein 1 (APLP1) and APLP2, have been shown to be involved in many processes including neuronal development, signal transduction, and neuronal homeostasis. APP metabolism in turn leads to amyloid-ß peptides, which have a predominant role in amyloid deposition in AD.

The rabbit polyclonal antibody against the phosphorylated threonine-688 (Cat.# 4BDX-1503) of APP can be used for Western blot, immunohistochemistry and immunofluorescence and is also a biomarker for neuritic processes surrounding amyloid deposits.

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