Comparison

Angiotensin A (1-8) European Partner

Item no. ALO-SPA-105-10mg
Manufacturer Alomone
CASRN 51833-76-2
Amount 10 mg
Quantity options 10 mg 25 mg 5 mg
Category
Type Peptides
Format Lyophilized
Applications FA
Specific against other
Purity ≥98% (HPLC)
Formula Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Sequence ARVYIHPF-OH
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Shipping Condition Room temperature
Available
Manufacturer - Type
Non Antibodies
Manufacturer - Applications
Aequorin functional assay / Calcium imaging assay
Manufacturer - Category
Proteins
Manufacturer - Targets
Angiotensin receptors
Country of Origin
Israel
Shipping Temperature
The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.
Storage Conditions
Storage as Solution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight
1002 Da
Manufacturer - Format
Lyophilized
Short description
A Potent Agonist of Angiotensin II Receptors  
Description
A Potent Agonist of Angiotensin II Receptors
Reconstitution
Centrifuge the vial (10, 000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Specificity

A Potent Agonist of Angiotensin II Receptors

PH
7, 4
UNSPSC
12352202
Effective Concentration
0.5 - 1 nM
Activity
An Angiotensin II Type 1 and Type 2 Receptor Agonist1.
Solubility
Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Sterile endotoxin free
no
Bioassay tested
yes
Scientific Background
Angiotensin A (1-8) is an angiotensin II derivative, a vasoconstrictor peptide of the renin-angiotensin system (RAS) that acts as an angiotensin receptor type 1 and 2 (AT1R and AT2R) agonist.This peptide was first discovered in the human plasma and the sole difference between Ang A and Ang II is Ala1 residue instead of Asp1. Ang A is synthesized by enzymatic decarboxylation of Asp1 of the Ang II sequence1.Angiotensin I is metabolized to the vasoconstricting octapeptide angiotensin II by a circulating converting enzyme (ACE) by removal of two C-terminal residues. It's a natural hormone which the body produces in order to maintain normal regulation of cardiovascular function.Ang II is a primary effector peptide of the RAS in a variety of tissues and is a major target for blood pressure lowering drugs2.Studies show that Ang A has the ability to elicit pressor and renal vasoconstrictor responses in normotensive and hypertensive rats. In isolated perfused rat kidney, the peptide causes a vasoconstrictive effect dependent on AT1 receptors1.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
available

Delivery expected until 12/4/2025 

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close