Manufacturer |
American Research Products
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Amount |
0.5 mg |
Item no. |
ARP-01-1748-0.5 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Description |
Ketohexokinase is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, leading to consumption of ATP, formation of AMP. This protein initiates first step in the metabolism of dietary fructose and is an important regulator of hepatic glucose metabolism. It is highly found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine. Recombinant human Ketohexokinase was expressed in E.coli and purified by using conventional chromatography. |
Form |
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol |
Storage |
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Synonyms |
KHK, Hepatic fructokinase, EC 2.7.1.3, Hepatic fructokinase, ketohexokinase, Ketohexokinase isoform a, |
Concentration |
1 mg/ml (determined by Bradford assay) |
NCBI |
AAH06233 |
References |
- Bonthron DT., et al. (2009) J Histochem Cytochem. 57(8):763-74.
- Schermerhorn T., et al. (2009) Res Vet Sci. 87(1):115-7.
|
Antigen Recognized in Species |
Human |
Purity |
>, 90% by SDS - PAGE |
Molecular Weight |
32.7 kDa (298aa), confirmed by MALDI-TOF. |
Amino Acid Sequence |
MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV |
Gene Category |
Metabolism |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.