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Glucosylceramide synthase-IN-2

Glucosylceramide synthase-IN-2

Manufacturer	MedChem Express
Category	Proteins
Type	Enzymes
Specific against	other
Amount	10mg
Item no.	HY-144267-10mg
CASRN	2597958-02-4
Available
Product Description	Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research.
StorageTemperature	4°C, sealed storage, away from moisture and light; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Applications	Metabolism-sugar/lipid metabolism
Formula	C22H20F3N3O4
References	[1].Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10; 65(5):4270-4290
MolecularWeight	447.41
Research Area	Metabolic Disease; Neurological Disease
Target	Others
Pathway	Others

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Amount: 10mg

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Delivery expected until 4/13/2023

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