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Glucosylceramide synthase-IN-2

Glucosylceramide synthase-IN-2

Item no.	HY-144267-10mg
Manufacturer	MedChem Express
CASRN	2597958-02-4
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Peptides & Proteins Enzymes
Type	Enzymes
Specific against	other
Purity	98.45
Formula	C22H20F3N3O4
Citations	[1]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
Smiles	O=C(C1=CC=NN(C1=O)C2=C(OCC(F)(F)F)C=CC=C2)NC3=CC=C(C(C)(O)C)C=C3
ECLASS 10.1	32160410
ECLASS 11.0	32160410
UNSPSC	12352204
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Glucosylceramide Synthase (GCS)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	447.41
Product Description	Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1].
Manufacturer - Research Area	Metabolic Disease; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Neuronal Signaling
Clinical information	No Development Reported

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HY-144267-10mg-safety-datasheet.pdf