Comparison

Glucosylceramide synthase-IN-2 European Partner

Manufacturer MedChem Express
Category
Type Enzymes
Specific against other
Amount 10mg
Item no. HY-144267-10mg
CASRN 2597958-02-4
Available
Product Description
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research.
StorageTemperature
4°C, sealed storage, away from moisture and light; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Applications
Metabolism-sugar/lipid metabolism
Formula
C22H20F3N3O4
References
[1].Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10; 65(5):4270-4290
MolecularWeight
447.41
Research Area
Metabolic Disease; Neurological Disease
Target
Others
Pathway
Others

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 10mg
Available: In stock
available

Delivery expected until 4/13/2023 

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