Comparison

Glucosylceramide synthase-IN-2 European Partner

Item no. HY-144267-50mg
Manufacturer MedChem Express
CASRN 2597958-02-4
Amount 50 mg
Quantity options 100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category
Type Enzymes
Specific against other
Purity 98.45
Formula C22H20F3N3O4
Citations [1]Yuta Tanaka, et al. Discovery of Brain-Penetrant Glucosylceramide Synthase Inhibitors with a Novel Pharmacophore. J Med Chem. 2022 Mar 10;65(5):4270-4290
Smiles O=C(C1=CC=NN(C1=O)C2=C(OCC(F)(F)F)C=CC=C2)NC3=CC=C(C(C)(O)C)C=C3
ECLASS 10.1 32160410
ECLASS 11.0 32160410
UNSPSC 12352204
Shipping condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Metabolism-sugar/lipid metabolism
Manufacturer - Targets
Glucosylceramide Synthase (GCS)
Shipping Temperature
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight
447.41
Product Description
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research[1].
Manufacturer - Research Area
Metabolic Disease; Neurological Disease
Solubility
DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway
Neuronal Signaling
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 mg
Available: In stock
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