Recombinant Human IL-17A/CTLA-8 Protein

< 0.1 EU/μg of the protein by LAL method.

ice pack

16.37 kDa

IL17, also known as IL17a and CTLA8, is a is a 15-20 kDa glycosylated cytokine which belongs to the IL-17 family. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL17A promotes protective mucosal and epidermal inflammation in response to microbial infection .It induces chemokine production, neutrophil influx, and the production of antibacterial peptides .IL17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF alpha induced shock . In contrast, it can protect against the progression of colitis by limiting chronic inflammation . IL17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity .

C-His

CTLA8, IL17, IL17A

1. Measured by its binding ability in a functional ELISA. Immobilized Recombinant human IL17RA at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A, the EC₅₀ of human IL-17A is 32. 5-130 ng/mL.|2. Measured by its ability to induce IL-6 secretion by Hela cells. The ED₅₀ for this effect is 2. 64-10. 58 ng/mL, corresponding to a specific activity of 9. 45×10⁴~3. 79×10⁵ units/mg.

16.37 kDa