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Recombinant Human LILRA4/ILT-7/CD85g Protein

Recombinant Human LILRA4/ILT-7/CD85g Protein

Item no.	RP02708-500ug
Manufacturer	Abclonal
Amount	500 ug
Quantity options	100 ug 500 ug
Specific against	Human (Homo sapiens)
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
NCBI	LILRA4/CD85g
Alias	CD85g,ILT7,ILT-7,ILT7MGC129598,LILRA4,MGC129597
Shipping condition	Cool pack
Available
Manufacturer - Applications	Less than 1EU per μg by the LAL method.
Manufacturer - Category	Proteins
Shipping Temperature	ice pack
Storage Conditions	Store at -20°C.Store the lyophilized protein at -20°C to -80°C up to 1 year from the date of receipt. \|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Protein Weight	49.5 kDa
Description	Recombinant Human LILRA4/ILT-7/CD85g Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu24-Asn446) of Human LILRA4/ILT-7/CD85g (Accession #) fused with His tag and Avi tag at the C-terminal.
Background	LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.
Manufacturer - Cross Reactivity	Centrifuge the tube before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
Immunogen	Glu24-Asn446
Route	C-His&Avi
Manufacturer - Research Area	Other Recombinant Protein
Expected Protein Size	49.5 kDa
Gene Symbol	LILRA4/CD85g

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

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Delivery expected until 6/26/2025

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