Manufacturer |
St John's Laboratory
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Applications |
WB |
Amount |
50ul |
Host |
Rabbit |
Item no. |
STJ114227-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9UBK2 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 700 to the C-terminus of human PPARGC1A (NP_037393. 1). |
Short Description |
Rabbit polyclonal against PPARGC1A |
Tissue specificity |
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. |
Cellular localization |
Isoform 1: NucleusNucleusPml BodyIsoform B4: NucleusIsoform B4-8a: CytoplasmIsoform B5: NucleusIsoform 9: Nucleus |
Molecular weight |
Calculated: 14kDa/30kDa/31kDa/33kDa/77kDa/89kDa/91kDa. Observed: 115kDa/120kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha antibodyAnti-Pgc-1-Alpha antibodyAnti-Ppar-Gamma Coactivator 1-Alpha antibodyAnti-Ppargc-1-Alpha antibodyAnti-Ligand Effect Modulator 6 antibodyAnti-PPARGC1A LEM6 PGC1 PGC1A PPARGC1 antibody |
Protein name |
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-AlphaPgc-1-AlphaPpar-Gamma Coactivator 1-AlphaPpargc-1-AlphaLigand Effect Modulator 6 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.