Manufacturer |
St John's Laboratory
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Applications |
WB |
Amount |
50ul |
Host |
Rabbit |
Item no. |
STJ115844-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P14618 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 11-221 of human PKM (NP_002645. 3). |
Short Description |
Rabbit polyclonal against PKM |
Tissue specificity |
Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells. |
Cellular localization |
CytoplasmNucleusTranslocates To The Nucleus In Response To Different Apoptotic StimuliNuclear Translocation Is Sufficient To Induce Cell Death That Is Caspase IndependentIsoform-Specific And Independent Of Its Enzymatic Activity |
Molecular weight |
Calculated: 56kDa/57kDa/58kDa. Observed: 65kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Pyruvate Kinase Pkm antibodyAnti-Cytosolic Thyroid Hormone-Binding Protein antibodyAnti-Cthbp antibodyAnti-Opa-Interacting Protein 3 antibodyAnti-Oip-3 antibodyAnti-Pyruvate Kinase 2/3 antibodyAnti-Pyruvate Kinase Muscle Isozyme antibodyAnti-Thyroid Hormone-Binding Protein 1 antibodyAnti-Thbp1 antibodyAnti-Tumor M2-Pk antibodyAnti-P58 antibodyAnti-PKM OIP3 PK2 PK3 PKM2 antibody |
Protein name |
Pyruvate Kinase PkmCytosolic Thyroid Hormone-Binding ProteinCthbpOpa-Interacting Protein 3Oip-3Pyruvate Kinase 2/3Pyruvate Kinase Muscle IsozymeThyroid Hormone-Binding Protein 1Thbp1Tumor M2-PkP58 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.