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Anti-NTRK2 antibody (41-433) (STJ114207)

Anti-NTRK2 antibody (41-433) (STJ114207)

Manufacturer	St John's Laboratory
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Cell Biology Cell Status Necrosis Adenocarcinoma Cytoskeleton Western Blot Primary Antibodies Microfilaments By Organ Colorectal Cancer Thyroid Cancer Neuronal Cell Markers
Type	Antibody Polyclonal
Specific against	Human, Mouse
Isotype	IgG
Applications	WB
Amount	50 ul
Host	Rabbit
Item no.	STJ114207-50
Targets	MYH14;;NTF3;;NTRK1;;NTRK2;;TRK-CTT2-3
eClass 6.1	32160702
eClass 9.0	32160702
Available
Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	Q16620
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
Gene ID	4915
Gene symbol	NTRK2
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 41-433 of human NTRK2 (NP_001007098. 1).
Short Description	Rabbit polyclonal against NTRK2
Tissue specificity	Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.
Cellular localization	Cell Membrane Single-Pass Type I Membrane Protein Endosome Membrane Early Endosome Membrane Cell Projection Axon Dendrite Cytoplasm Perinuclear Region Cell Junction Synapse Postsynaptic Density Internalized To Endosomes Upon Ligand-Binding
Molecular weight	Calculated: 35kDa/53kDa/59kDa/60kDa/81kDa/91kDa/93kDa. Observed: 105kDa
Dilution range	WB 1:500-1:2000
Alternative names	Anti-Bdnf/Nt-3 Growth Factors Receptor antibody Anti-Gp145-Trkb antibody Anti-Trk-B antibody Anti-Neurotrophic Tyrosine Kinase Receptor Type 2 antibody Anti-Trkb Tyrosine Kinase antibody Anti-Tropomyosin-Related Kinase B antibody Anti-NTRK2 TRKB antibody
Protein name	Bdnf/Nt-3 Growth Factors Receptor Gp145-Trkb Trk-B Neurotrophic Tyrosine Kinase Receptor Type 2 Trkb Tyrosine Kinase Tropomyosin-Related Kinase B
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	NTRK2_HUMAN

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ul

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Delivery expected until 5/23/2024