Manufacturer |
St John's Laboratory
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse |
Isotype |
IgG |
Applications |
WB, IF, IHC |
Amount |
100ul |
Host |
Rabbit |
Item no. |
STJ114384-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q96SB4 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors. Alternative splicing of this gene results in multiple transcript variants. Additional alternatively spliced transcript variants have been described for this gene, but their full length nature have not been determined. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 290-480 of human SRPK1 (NP_003128. 3). |
Short Description |
Rabbit polyclonal against SRPK1 |
Tissue specificity |
Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. Highly expressed in different erythroid and lymphoid cell lines, with isoform 2 being far more abundant than isoform 1. |
Cellular localization |
Isoform 2: CytoplasmNucleusNucleus MatrixMicrosomeShuttles Between The Nucleus And The CytoplasmInhibition Of The Hsp90 Atpase ActivityOsmotic Stress And Interaction With Hhv-1 Icp27 Protein Can Induce Its Translocation To The NucleusKat5/Tip60 Inhibits Its Nuclear TranslocationIsoform 1: CytoplasmMainly Localized In The Microsomal Fraction And The CytoplasmAnd To A Lesser Extent In The Nuclear Matrix |
Molecular weight |
Calculated: 72kDa/74kDa/92kDa. Observed: 102kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:100 |
Alternative names |
Anti-Srsf Protein Kinase 1 antibodyAnti-Sfrs Protein Kinase 1 antibodyAnti-Serine/Arginine-Rich Protein-Specific Kinase 1 antibodyAnti-Sr-Protein-Specific Kinase 1 antibodyAnti-SRPK1 antibody |
Protein name |
Srsf Protein Kinase 1Sfrs Protein Kinase 1Serine/Arginine-Rich Protein-Specific Kinase 1Sr-Protein-Specific Kinase 1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.