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Recombinant Human Vitamin K-dependent protein S(PROS1)

Recombinant Human Vitamin K-dependent protein S(PROS1)

Manufacturer	Cusabio
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Format	Liquid or Lyophilized powder
Amount	50ug
Host	E.coli
Item no.	CSB-EP018754HU-50
eClass 6.1	34160400
eClass 9.0	42020190
Available
Research areas	Cardiovascular
Target / Protein	PROS1
Biologically active	Not Test
Expression system	E.coli
Species of origin	Homo sapiens (Human)
Uniprot ID	P07225
AA Sequence	ANSLLEETKQGNLERECIEELCNKEEAREVFENDP ETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLR SCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCK PGWQGEKCEFDINECKDPSNINGGCSQICDNTPGS YHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAV CKNIPGDFECECPEGYRYNLKSKSCEDIDECSENM CAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVS VCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEIS RFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRG GKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEEL EHSISIKIAKEAVMDINKPGPLFKPENGLLETKVY FAGFPRKVESELIKPINPRLDGCIRSWNLMKQGAS GIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHID YNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNN TVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALS LCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQ RQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFY NGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWK KTKNS
Tag Info	N-terminal 6xHis-SUMO-tagged
Expression Region	42-676aa
Protein length	Full Length of Mature Protein
MW	86.6 kDa
Relevance	Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
References	Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing.Ploos van Amstel H.K., van der Zanden A.L., Reitsma P.H., Bertina R.M.FEBS Lett. 222:186-190(1987)
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Involvement in disease	Thrombophilia due to protein S deficiency, autosomal dominant (THPH5); Thrombophilia due to protein S deficiency, autosomal recessive (THPH6)
Subcellular Location	Secreted
Tissue Specificity	Plasma.
Paythway	Complementandcoagulationcascades
Tag Information	N-terminal 6xHis-SUMO-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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