Comparison

Recombinant Human Vitamin K-dependent protein S(PROS1)

Manufacturer Cusabio
Category
Type Proteins Recombinant
Specific against Human
Format Liquid or Lyophilized powder
Amount 1mg
Host E.coli
Item no. CSB-EP018754HU-1
eClass 6.1 34160400
eClass 9.0 42020190
Available
Research Areas
Cardiovascular
Target / Protein
PROS1
Biologically Active
Not Test
Expression System
E.coli
Species of origin
Homo sapiens (Human)
Uniprot ID
P07225
AA Sequence
ANSLLEETKQGNLERECIEELCNKEEAREVFENDP ETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLR SCVNAIPDQCSPLPCNEDGYMSCKDGKASFTCTCK PGWQGEKCEFDINECKDPSNINGGCSQICDNTPGS YHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAV CKNIPGDFECECPEGYRYNLKSKSCEDIDECSENM CAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVS VCLPLNLDTKYELLYLAEQFAGVVLYLKFRLPEIS RFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRG GKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEEL EHSISIKIAKEAVMDINKPGPLFKPENGLLETKVY FAGFPRKVESELIKPINPRLDGCIRSWNLMKQGAS GIKEIIQEKQNKHCLVTVEKGSYYPGSGIAQFHID YNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNN TVPFAVSLVDSTSEKSQDILLSVENTVIYRIQALS LCSDQQSHLEFRVNRNNLELSTPLKIETISHEDLQ RQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFY NGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVWK KTKNS
Tag Info
N-terminal 6xHis-SUMO-tagged
Expression Region
42-676aa
Protein Length
Full Length of Mature Protein
MW
86.6 kDa
Distributor Discount
50% off the list price
Relevance
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Reference
Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing.Ploos van Amstel H.K., van der Zanden A.L., Reitsma P.H., Bertina R.M.FEBS Lett. 222:186-190(1987)
Purity
Greater than 90% as determined by SDS-PAGE.
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20C/-80C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Involvement in disease
Thrombophilia due to protein S deficiency, autosomal dominant (THPH5); Thrombophilia due to protein S deficiency, autosomal recessive (THPH6)
Subcellular Location
Secreted
Tissue Specificity
Plasma.
Paythway
Complementandcoagulationcascades
Tag Information
N-terminal 6xHis-SUMO-tagged

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1mg
Available: In stock
available

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